How Far Do You Agree That the 1867 Reform Act Was Sucessfulte Essay Example for Free

How Far Do You Agree That the 1867 Reform Act Was Sucessfulte Essay Additionally, the 1867 Reform Act also had a significant impact on the issues that were being addressed by politics. Whereas before, the aristocracy had basically decided what happened in the country, the act meant that issues were being brought to light that had never been discussed properly in public before. This was very important as it not only changed public but it also changed society too. Issues such as the legislation surrounding drinking, education and taxation were now being impacted on by the public actually expressing their feelings about them and this determined that the act had changed entirely how people viewed politics by shifting their focus from the individuals within politics to the actually political interests that they represented. For the first time, the act seemed to allow working-class people to feel indignant at how they were labelled uneducated within society and how they were blamed for society. It could be said that the Reform Acts most important outcome was encouraging people to now speak up for what they believe in and to create a true democracy by exposing the flaws of the current political system that had kept hidden a system of suppression underneath a pretence of democracy. On the other hand, this outcome can be seen once again to only be attributing more to the argument that the most important outcome of the 1867 Reform Act was that that it had on the political parties. Whilst it did change the people, it also meant that individuals like Gladstone and Disraeli had to develop stronger personalities, more influential public speaking and just generally a more recognisable persona to get attention off the people and this changed politics, starting to transform it to what we recognise today with politicians attending school fairs and opening museums to get positive publicity. Whilst all of these outcomes were extremely important at the time, perhaps the most long-term and recognisable of all of the outcomes was the effect that the 1867 Reform Act did have on the political system and in particular, on the Liberals and Conservatives parties. Source 7 supports this view by introducing us to the idea of the political machine. The source shows how the Reform Act of 1867 meant that the political parties had to actually properly compete and make, sometimes unrealistic promises, to appeal to voters. It shows how this means that electioneering, the way the parties portrayed themselves and presentation of issues became much more important as politics became national and rotated around moral issues. Indeed this view does have a lot of weight in an argument. The political parties now were having to tread a careful line and keep a balance between the conflict of alienating the people with revolutionary political ideas and immediate actions to secure themselves as the strongest political parties. This meant that the Liberals and the Conservatives had to become united and professional. This impact was important as it meant that the political loyalty was created that we can recognise in politics today. Previously, parties had split up and conflicted over issues but following the act, politicians were forced to admit that they had to remain loyal to their own political party in order to get any success within the political circumstances. This outcome is so significant as it created the strong link that still exists today between political parties and the voters. The two different parties had to go to what they saw as extreme lengths to secure voters loyalty and to encourage them to vote. This included the setting up of party clubs and trips to places such as the seaside as rewards for people who promised to vote for a certain political party. In a way, it shows how this outcome was significant in advancing political organisation and professionalism yet in other ways it just maintained the old influential schemes that politicians used but at last, they had to actually be clever to use these rather than to blatantly bribe and influence people. They could still influence people, just as they had done with the open ballots, but this time they had to do it with rewards and false promises. To a certain extent, this can still be seen to be happening in our political system today. In conclusion, there were many outcomes of the 1867 Reform Act and all of these were significant in their own way. The impact of these can be seen clearly by the fact that they have triggered features of our own political system today, such as strong political personalities for politicians and image-conscious newspapers and magazines. However, these all contributed to allowing the Liberals and the Conservatives parties to change and whilst individually they were significant impacts, the effect that they had on electorate always corresponded with an effect on the political parties. In this way, the most significant outcome of the 1867 Reform Act was the impact that it had on the Liberals and the Conservatives parties yet this would not have been significant or even have occurred independently of the impact that the act on the electorate themselves. This means that whilst we can identify an outcome of the act as the most important, it simply would not have had the effect that it did have without the other outcomes of the act, meaning that collectively they are important and making it extremely difficult to label the importance of the outcomes.

Expository Writing Essay -- Teaching Education

Expository Writing I really don't have any idea on where to start this paper, where it should go, and how it should end. It seems that I'm having a slight problem grasping the idea of expository writing. It's like when you were a kid trying to make it all the way across the monkey bars. You want to be able to reach that next rung and you try very hard, but somehow you just can't reach it. I seem to be having that problem. Right now, as I write, I'm not exactly sure I'm reaching the goal of this assignment, but this may be the best that it gets. All through elementary school, high school, and my freshman year of college, I was taught (and believed it was the only right way) that you must start your paper with a introduction, followed by the body of the paper, and wrap up your main thoughts in the conclusion. Although, in the past three weeks, I have learned that writing can go beyond those boundaries. Now, isn't that a shock after all these years of "formal education". It just doesn't seem right not to construct a paper in the way I have always done in the past, or should I say as this bad habit I've always had. But is actually bad? It always appeared to fit me just right. I am not planning a career in writing. I only want to add and subtract numbers, things that make sense to me. These are the things I understand, to some extent anyhow. There is no alternate interpretation of fourteen minus seven. It will always be seven, no matter how you look at it or who looks at it. It will always be seven. There is one definite answer and if you get it wrong, you're just plain wrong. No ifs, ands, or buts about it. No one can decide that on some particular day that fourteen minus seven is eight. It is impossible. The answer will, f... ...convey your message and get the reaction(s) you want, what is there to change? How about leaving well enough alone? If it's not broke, why fix it? As I look back through this paper, I am not certain I have met the requirements of this writing assignment. I feel as though I am still trying the reach that next bar on the monkey bars as I did when I was young. No matter how much I struggle and lunge for the next rung, it is just barely out of my reach. But in all actuality, is that what I'm really trying to accomplish? Is just reaching the next rung my main objective? No, reaching the end of the monkey bars is my goal. As for right now, I would be happy just reaching that next rung. As my first paper in approximately two years, I hope it is not too terribly bad. As the quarter progresses, I hope to improve in this writing style that is all too new and foreign to me.

Alkylation agents as Chemotherapeutic agents

Chemotherapy simply means the use of chemicals to treat disease by destroying microorganism or cancerous or tumor cells. Generally, chemotherapy acts by destroying rapidly dividing cells although the mechanism that leads to this differs. Several divisions of chemotherapy agents exist such as the anti-metabolites, plant alkaloids the topoisomerase inhibitors, anthracyclines and alkylation agents which are discussed in this paper. Generally, alkylation agents work by addition of alkyl groups to the guanine of DNA molecule at number 7 atom of imidazole group (Siddik, 2002).Alkylation agent’s significance The name originates from their ability to alkylate several nuclophilic functional categories in certain cellular conditions . Examples of alkylation agents are carboplatin, oxaliplatin and cisplatin that work by covalent bond formation with specific carboxyl, sulphurhydril and phosphate groups in molecules of biological importance (Siddik, 2002). These are regarded as platinum-ba sed alkylation agents. These platinum based alkylation agent are divided into first, second and third generations made up of cisplatin,caboplatin and oxaliplatin respectively.They found important use in treatment of mesothelioma . They work at all stage of cell cycle and impair cellular DNA synthesis as well as transcption (Siddik, 2002). Cisplatin is used to treat lung and testicular cancers. Other alkylation agents include chlorambucil, mechlorethamine, ifosfamide and cyclophosphamide as well as procarbazine and bulsulphan. Alkylation agents are effective at all stage of cell cycle making them useful in treating wide range of cancer especially the slow growing ones like solid tumor and leukemia (Pizzo & Poplack, 2006)All share biochemical mechanism although they may differ in their clinical effects. The significance of alkylation agents is not only seen in treatment of leukemia, lymphomas and solid tumors. They are also found significant in the treatment of non neoplastic conditio ns such as cyclophosphamide use in treatment of autoimmune disease . Pulse dose cyclophosphamide is used in lupus nephritis and other conditions like Wegener’s granulomatosis, multiple sclerosis and rheumatoid arthritis (Siddik, 2002).They are not however free of side effects especially after prolonged use and these include amenorrhea (cessation of menses), oligospermia (reduction in sperm count) as well as secondary cancers such as acute myelogenous leukemia (Pizzo & Poplack, 2006). General classification of alkylating chemotherapeutic agents ? Non-specifically acting agents: They crosslink guanine nucleobases present in double helix of DNA and by so doing stop tumor proliferation. ? Agents that need activation : This includes cyclophosphamide which needs in-vovo conversion to active product? Biakylating and Monoakylating agents: The biakylating agents are capable of reacting with two 7-N guanine residues. When these residues are in different DNA strands, there is resulting crosslinkage of DNA strands and this makes DNA double helix to fail to uncoil (Siddik, 2002). However, when the two guanine moieties are in same base strands, what occurs is known as limpet association of DNA to the drug molecule. Example of biakylating agent is Bulsuphan . On the contrary, monoakylating agents are only capable of reacting with one 7-N of guanine molecule.? Classical alkylation agents: These are termed alkyl groups and they include three subgroups which are: (a) the nitrogen mustards which include mephalan, ifosfamide, uramustine, chlorambucil, mechlorethamine and cyclophosphamide b) The nitrosoureas which are carmustine, streptozocin and lomustine c) the alkyl sulphonates such as bulsuphan. ? Alkylation-like agents: They lack alkyl group but destroy DNA. They are regarded as alkylation-like as they coordinate to DNA so as to interrupt DNA repair permanently.They are the platinum based drugs such as cisplatin,oxaliplatin and carboplatin. They also bind at N7 positio n of guanine (Siddik, 2002) ? The Non-classical: Certain categories are termed non-classical such as altremine and procarbazine. Furthermore, sometimes the platinum based drugs are also regarded as non-classical. Nitrogen Mustards The nitrogen mustards are a group of DNA alkylation agents which are not specific . They are cytotoxic and have similar qualities to mustard gas, hence utilized as medicinal and chemical warfare agents.Nitrogen mustards stockpiled by many countries in WW II serve as potent and useful blister agents. Nitrogen mustards suppress bone marrow production of red blood cells. The first nitrogen mustard developed was mustine with anti-neoplastic chemotherapeutic value. Other examples of alkylation agents in nitrogen mustard family are mephalan, cholambucil, cyclophosphamide, uramustine and ifosfomide (Siddik, 2002). The likes of Bis (2-chloroethyl) ethylamine and Tris (2-choloroethlamine) are few nitrogen mustards used in chemical warfare.Nitrogen mustard’s mode of action involves formation of aziridinium or cyclic aminium ion when the amine nitrogen displaces chloride at intermolecular level. This is then followed by alkylation of DNA centers by the azidirium group (Siddik, 2002). Malfunctioning of alkylation DNA is usual during replication (Pizzo & Poplack, 2006). They prevent cell division and by so doing cause abnormal base pairing. Also it is possible that more than a single alkylation groups may exist in each molecule .In order words, these therapeutically useful alkylation agents are either bialkylating or polyalkylating agents (Siddik, 2002). The damaging effect is comparable to that which is seen with exposure of genetic material to radiation making it radiometric. Earlier, nitrogen mustards have been shown to form interstrand crosslinks (ICLs) and this formation takes place between N-7 of guanine residue in a 5†²-d (GC) sequence, although it was later discovered that nitrogen mustards form a 1,3 Interstrand crosslinks in the 5†²-d (GNC) sequence (Siddik, 2002).For instance, cyclophosphamide (cytophosphane), a nitrogen mustard arise from oxazophorine group and exhibits their chemotherapeutic effects by its nitrogen mustard metabolite,phosphoramide which form both interstrand and intrastrand crosslinkages at N-7 position of guanine molecule causing cell death. Cyclophosphamide metabolite is usually produced in cell with low amount of ALDH. References Pizzo, P. A & Poplack, D. G. (2006). Principles and practice of pediatric oncology. Lippincott Williams & Wilkins.pp. 310-320. Siddik, Z. H (2002)Mechanism of action of Cancer chemotherapeutic agents; DNA-Interactive alkylation agents and Antitumor platinum based Drugs. Retrieved On August 15,2010 from http://webcache. googleusercontent. com/search? q=cache:brnWwlXCLnIJ:hasdl. kau. edu. sa/encyclopedia/2/h6%2520archive/17. pdf+Mechanisms+of+Action+of+Cancer+Chemotherapeutic+Agents:+DNA-Interactive+Alkylating+Agents+and+Antitumour+Platinum-Based+Drug s+by+Zahid+H. +Siddik&cd=1&hl=en&ct=clnk

Smoking Addiction Essay - 1040 Words

Smoking Addiction Smoking is an extremely addictive habit that usually forms in the early teen years. We should be targeting our children from the time they enter elementary school to prepare them for this temptation and encourage them to steer clear of this problem (Schoebel 287). There is no sure cure for smoking, and every method requires willingness, dedication, and will power. Smokers should recognize the serious health risks they are facing every time they light a cigarette and accept that quitting such an addictive habit would only come with some amount of discomfort. Is there anyone who does not know someone who smokes? Everyone has a family member, friend, or coworker who smokes. They have chosen to smoke, but by just being†¦show more content†¦This disease is killing people if it is not detected promptly. Another reason for quitting smoking is heart disease and its consequences. For example, many people suffer from heart failure, but even though they know about smoking and its dange rs, they do not stop their habit until they become ill. Unfortunately, in many cases, people are at risk to live with heart complications for the rest of their lives. Lastly, another important reason for people to stop smoking is the risk of getting emphysema. This is also a deadly disease that affects their lungs and their whole respiratory system. These several reasons should prove to the smokers that this habit puts their health in danger, and causes many diseases that lead to death (Dhillion 198) . Cigarettes also tend to be an appetite suppressant specifically decreasing the appetite for simple carbohydrates and disturbs the efficiency with which food is metabolized. People who use tobacco products frequently depend upon it to provide these side effects to help them accomplish certain tasks at specific levels. The reason cigarette smokers do not give up this harmful habit easily is simple; Nicotine is a highly addictive substance like many other drugs. Smokers are hooked as surely as is any heroin or cocaine addict; giving up cigarettes creates painful withdrawal symptoms and a craving that many people cannot overcome (Dhillion 212). Nicotine is carried to the brain via the bloodstream within a minute orShow MoreRelatedTeenage Addiction to Smoking1498 Words   |  6 Pagestime society has battled the causes of addiction. Addiction has desecrated the nation’s health and has defiled the health of future generations. The hostile impact on young generations, addiction to smoking cigarettes is staggering. Smoking has taken an enormous toll on the minds and health of young teens around the world. Teenage smoking is an epidemic that has derives from several causes. Smoking in young teens has become more common this day in age. 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The reason for that is because my loved one has already attempted to stop her addiction but always failed. Knowing that I felt that it was going to be another fail. Mostly I was scared of how she was going to react when I told her about what I wanted to do. I was also excited and happy that maybe this time she will actually be bale to overcome Her addiction, because she would have me by her side pushing and encouraging her to go on with it. I choose this projectRead MoreThe Effects Of E Cigarettes On The Health Organization1503 Words   |  7 Pagese-cigarette. E-cigarettes are battery-powered devices that create a vapor mist from a heated liquid solution when the user inhales on a mouthpiece (Wagaman). As of their creation in 2006, a growing number of people are taking up â€Å"vaping† instead of smoking, resulting in an industry worth $2.7 billion worldwide (Senthilingam). 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